Geref (sermorelin acetate) prescribing information (US FDA)
The original approved labeling documents sermorelin's pharmacology and its diagnostic use in assessing growth hormone secretion.
Longevity
Sermorelin
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). It was an FDA-approved medication until 2008 and is now prepared by compounding pharmacies. Here is what it is, what the evidence does and does not show, and how it works through a licensed physician.
Compounded. Not FDA-approved as a finished product today. Available by prescription only.
GHRH analog
29 amino acids
Compounded
Prescription only
$149/mo — billed through your protocol
Physician-reviewed before it ships
What it is
What sermorelin is
Sermorelin, or sermorelin acetate, is a synthetic peptide made of the first 29 amino acids of human growth hormone-releasing hormone, the natural signal the body uses to prompt the pituitary gland to release growth hormone. That 29-amino-acid fragment is the active part of the full 44-amino-acid hormone. Pharmacologically, it raises growth hormone by stimulating the pituitary to release it, rather than supplying growth hormone directly. It was first approved by the FDA in 1997 under the brand name Geref. Beyond that established mechanism, we make no claims about what sermorelin will do for you. Whether it fits your goals is a decision for a licensed physician.
The evidence
What the research says, and what it does not
Sermorelin's mechanism is well established, and the FDA approved it decades ago for a diagnostic use, assessing how well the pituitary releases growth hormone. The evidence for the wellness and age-management uses people explore today is much thinner. The original approval was for diagnosis, not for anti-aging or body composition, and there are no large modern human trials supporting those uses. We present the research so you can be informed and ask your physician detailed questions. We make no claims about what sermorelin will do for you.
Khorram et al. (1997) — administration of GHRH in older adults
A commonly cited early human study on GHRH and the aging growth hormone axis. Described neutrally; it does not establish a wellness benefit.
[[Final curated study list and one-line descriptions to be supplied and vetted by the doctor network and counsel. Cite title, year, journal, link — with our own neutral descriptions, not pasted abstracts.]]
The specifics
Molecular profile
- Class
- GHRH analog · GRF(1–29)NH₂
- Molecular formula (free base)
- C₁₄₉H₂₄₆N₄₄O₄₂S
- Molecular weight
- ~3,358 g/mol
- CAS number (acetate)
- 114466-38-5
- Sequence
- Amidated 29-residue N-terminal fragment of human GHRH
Physical properties
- Form
- Sterile lyophilized powder
- Reconstituted pH
- 5.0 to 5.5
- Route
- Subcutaneous injection (reconstituted before use)
Specs match the historical FDA label. [[Confirm against the pharmacy certificate of analysis before publishing.]]
Safety
Safety and what to discuss with your physician
Sermorelin is generally well tolerated. The most commonly reported effects are reactions at the injection site, such as redness, swelling, or discomfort. Some people have reported flushing, headache, dizziness, nausea, or a change in taste. Because it acts on the growth hormone system, a licensed physician reviews your history, decides whether it is appropriate for you, and monitors you while you are on protocol. People who are pregnant or breastfeeding, and anyone with a significant medical condition, should review it with a physician first. Competitive athletes should note that growth hormone secretagogues, including sermorelin, are prohibited under WADA rules.
The process
How to get sermorelin through Xceed
01
Tell us your goal
Complete a short medical intake.
02
A physician decides
If a protocol is right for you, they prescribe it. If it is not, they tell you.
03
Delivered, with a coach
A US-based pharmacy dispenses it, and the Avida app and a coach come with it.
Was.Approved 1997–2008 · not today
Was sermorelin FDA-approved?
Yes, historically. Sermorelin was approved by the FDA in 1997 under the brand name Geref and was discontinued in 2008 for commercial reasons, not safety. There is no FDA-approved sermorelin product on the market today. The sermorelin available now is compounded by a licensed pharmacy and is not FDA-approved as a finished product. It is prescribed by a licensed physician and dispensed by a licensed US-based pharmacy.
Questions
Frequently asked questions
Is sermorelin FDA-approved?
It was, as Geref, until 2008. There is no FDA-approved sermorelin product today. What you would receive is compounded and is not FDA-approved as a finished product.
What is sermorelin?
A synthetic peptide, the first 29 amino acids of growth hormone-releasing hormone, that stimulates the pituitary to release growth hormone.
Do I need a prescription?
Yes. A licensed physician reviews your intake and decides whether it is appropriate before anything is dispensed.
How is it taken?
By subcutaneous injection. Your physician sets the specifics.
What does the evidence show?
Its mechanism is well established and it was approved for a diagnostic use. Evidence for today's wellness and age-management uses is limited, and we do not claim a result.
Can competitive athletes use it?
Growth hormone secretagogues, including sermorelin, are prohibited under WADA rules. Athletes subject to anti-doping should not use it without understanding that.
How is quality assured?
It is compounded by a licensed US-based pharmacy and, where applicable, batch tested. [[Confirm testing specifics with the pharmacy.]]
Start here
Want to talk to a physician about sermorelin?
Start with a short intake. A licensed physician decides what, if anything, is right for you.